Endocrine Abstracts

An 82 year old lady was admitted with acute stroke on 3/1/18, confirmed on MRI. She was found to be in AF and had thyroid function tests checked on 4/1/2018, with TSH 0.01 (0.27–4.20) mIU/l and FT4 52.8 (12.0–22.0) nmol/l. She was commenced on Carbimazole 20 mg OD. TPO and TSH-receptor antibodies were both negative. An ultrasound scan confirmed a normal thyroid without any features of Grave’s disease or thyroid nodules. Clopidogrel 75 mg OD and Atorvastatin 40 m...

Introduction: 46,XX disorder of sexual development (DSD) is a rare cause of sex reversal. Only a few hundred cases have been described. The clinical spectrum can be divided into 3 groups of males according to genital appearance: normal male, atypical variants such as hypospadias or cryptorchidism, and those with both male and female genitalia.Subcategories of 46,XX DSD include ovotesticular DSD, which is characterised by the presence of both testicular a...

Patients with chronic schizophrenia and psychosis are prone to develop hyponatremia secondary to psychogenic polydipsia. Hyponatremia secondary to water intoxication and its rapid correction are linked with rhabdomyolysis, an under-recognized yet serious condition. We report a case of 31 year old male with schizophrenia on Risperidone, who was brought to the emergency due to an unwitnessed fall and confusion. Serum sodium was 111 mmol/l, urine osmolality 55 mosm/kg and urine s...

Introduction: Periodic paralysis is a rare condition characterized by muscle weakness in the presence of triggers including cold, heat, high carbohydrate meals or physical activity. It is classically described in the presence of profound hypokalaemia; when this occurs in conjunction with thyrotoxicosis it is termed thyrotoxic periodic paralysis.Case history: A 30-year old Nigerian man presented with a 3 h history of inability to move, on a background of ...

Benign Ethnic Neutropenia (BEN) is a common form of neutropenia defined as an absolute blood neutrophil count (ANC) of < 1.5 x 109/l, usually observed in Afro-Caribbeans. These patients are not at increased risk of infection despite their neutropenia, unless they are on medications which can cause neutropenia. Amongst these drugs antithyroid medications are known to cause agranulocytosis defined as ANC of <500/μl. We report a case of 24 years old male w...